Planar cell polarity genes, Celsr1-3, in neural development
نویسندگان
چکیده
منابع مشابه
Mutations in the planar cell polarity genes CELSR1 and SCRIB are associated with the severe neural tube defect craniorachischisis.
Craniorachischisis (CRN) is a severe neural tube defect (NTD) resulting from failure to initiate closure, leaving the hindbrain and spinal neural tube entirely open. Clues to the genetic basis of this condition come from several mouse models, which harbor mutations in core members of the planar cell polarity (PCP) signaling pathway. Previous studies of humans with CRN failed to identify mutatio...
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ژورنال
عنوان ژورنال: Neuroscience Bulletin
سال: 2012
ISSN: 1673-7067,1995-8218
DOI: 10.1007/s12264-012-1232-8